The Inflammation Solution I Wish I Knew Sooner: Why I Take Pro-Resolving Mediators (Not Just Fish Oil)

If you’ve ever wondered why your joint pain, brain fog, bloating, or hormone imbalance isn’t budging even though you’re eating clean, exercising, and taking your Omega-3s… you’re not alone.

I was in the same boat.In fact, on my most recent functional lab work — even with a high-quality fish oil supplement in my daily stack — I tested deficient in Omega-3s. 🤯

As someone with Hashimoto’s, a condition rooted in systemic inflammation, this was a wake-up call. I’d been doing all the things to support my healing. But inflammation? Still running the show.

That’s when I discovered Pro-Resolving Mediators (PRMs) — and I’m telling you, they changed everything.

Wait, What Are PRMs?

Think of PRMs (also called SPMs, short for specialized pro-resolving mediators) as the cleanup crew your body calls in after an inflammatory response. They’re molecules your body should make from EPA and DHA (the Omega-3s in fish oil). But:

• Aging, chronic stress, autoimmune issues (hello Hashimoto’s), and alcohol all impair this conversion.

• You might be taking Omega-3s but not actually making PRMs — which means the inflammation keeps smoldering in the background.

This was exactly what was happening in my body.

My Personal Experience: What Changed When I Added PRMs

When I added a high-quality PRM supplement to my routine (alongside my regular fish oil, which also includes curcumin for even more inflammation support), I noticed:

✨ Less joint pain — Like, dramatically less✨ More energy and mental clarity✨ Improved sleep✨ And here’s the kicker: my Hashimoto’s antibodies dropped for the first time since I was diagnosed.

Coincidence? I don’t think so. This was the first time I felt like I was actually resolving inflammation instead of just managing it.

What Makes PRMs Different from Fish Oil?

While fish oil is great, PRMs are next level:

Fish Oil (EPA/DHA)	Pro-Resolving Mediators (PRMs)
Raw materials for inflammation resolution	Active molecules that actually resolve inflammation
Must be converted in the body	Already converted — no middle step
Supports cardiovascular + brain health	Directly targets immune response + chronic inflammation
Absorption can be variable	Liposomal PRMs = high bioavailability

Think of PRMs as the difference between giving your body the ingredients and handing it the finished product.

And yes — I still take both. My fish oil includes liposomal curcumin, which helps lower inflammation in a different pathway and enhances absorption. But the PRMs are the real game-changer.

Who Should Consider PRMs?

If you’re navigating…

• Autoimmunity (Hashimoto’s, RA, etc.)

• Chronic stress or post-viral fatigue

• Alcohol recovery or hormone rebalancing

• Perimenopause symptoms (especially joint pain, brain fog, or mood swings)

• Stubborn inflammation that’s not responding to diet and lifestyle alone

…you need to know about PRMs.

Best Practices for Taking PRMs

🧪 Choose a high-quality brand — Look for SPM Active or PRM-specific supplements from reputable companies.

🕘 Take with food for better absorption.

📈 Stay consistent — It took about 4–6 weeks for me to feel the full benefits.

💊 Keep your fish oil — They work synergistically, especially if your Omega-3 levels are low like mine were.

Final Thoughts: If You’re Still Inflamed, It’s Not Your Fault

We’re taught to "fight inflammation" with exercise, food, and basic supplements — but few people talk about the resolution phase.

Adding PRMs was the missing link in my healing. And honestly? It’s something I wish I’d known years ago.

If you’re still tired, puffy, or stuck in low-grade inflammation despite doing everything right — this might be your next best step.

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